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What does a systematic disease affect?

  1. Only the skin's surface

  2. Only the external extremities

  3. Internally throughout the body system

  4. Only a specific organ

The correct answer is: Internally throughout the body system

Systematic diseases are conditions that affect the entire body and can involve multiple systems or organs. These can include cardiovascular diseases, autoimmune disorders, and metabolic disorders. Option A and B are incorrect because they refer to only one part of the body rather than all systems or organs. Option D is incorrect because systematic diseases do not only affect a specific organ, but instead affect the entire body.